The understanding of wound healing has led to the inclusion of tissue regeneration therapy as an armamentarium to deal with both acute and chronic wounds. The bio constructs that aid in wound regeneration was made using natural, artificial, or a combination of both, widely known as regeneration scaffolds. The components of regeneration scaffolds promote the inherent self-renewal property of the skin and speed up the healing process by providing growth factors/stem cells. The scaffolds are in use for so many years. But the commercially available scaffolds are very expensive. Hence an indigenous scaffold was made use of multiple components like non-cultured keratinocytes, amniotic membrane, collagen, and silicone. Which was found to be in no way inferior to any of the commercially available scaffolds. Keywords: Regeneration Scaffold; Post Burn Raw area; Dermal Regeneration; Regenerative Therapy.