Background: In this study, we aimed to evaluate the value of FNAC in the diagnosis of solitary thyroid nodule, and asses the correlation with the histopathology. Materials and Methods: Prospectively FNACs of 90 cases of solitary thyroid nodule was compared with histopathology from July 1 2013 till June 31 2015. Results: The sensitivity and specificity of FNAC in our study is 77.7% and 98.7 respectively, the positive predictive value and negative predictive value is 87.5% and 97.5%respectively. Discussion: In our study, FNAC is proved to be an invaluable tool for pre-operative diagnosis of thyroid lesions, and its Bethesda system concords with histopathology results. Keywords: Solitary thyroid nodule; Fine needle aspiration cytology; Thyroid malignancy; Sensitivity; specificity.