Aim and Background: Percutaneous Nephrolithotomy (PCNL) is the primary treatment in renal stones more than 2 cms, staghorn calculi and
diffult stone to fragment with ESWL. Outcome of stone disease with PCNL was studied here. 
Materials and Methods: A prospective observational study was done in our institution to find the PCNL outcome/complications in relation to Guy’s Stone Score (GSS). Statistical analysis was done by using
Fisher's Exact Test, and ANOVA accordingly. P Value of <0.05 was considered significant.
Results: Total 50 PCNL were done. There were 25 males and 25 females. The mean age was 42.48 years. The mean stone burden average was 2.882 cm with a minimum of 2.5 cm and a maximum of 4 cm. Total complications noted was 25 (50%), but most were managed conservatively. As the GSS score increases the residual stones,
complications, operation time and length of hospital stay also increases (P Value <0.05). Conclusion: Increase in GSS associated with increase in residual, complications, operation time and length of hospital stay.
Keywords: Percutaneous Nephrolithotomy;
Complications; Outcome.