Context: Surgical correction of uncomplicated hypospadias involves bringing the meatus closer to ventral tip and correction of any presence of chordee. These genital repairs are performed when patients are young. Increasing the length of penis may have an additional advantage in these repairs. Aims: Study objectives were to explore the functional and cosmetic outcomes of use of parenteral testosterone and its effect on reducing postoperative complications. Settings and Design: A randomized prospective study was conducted amongst patients who were diagnosed with hypospadias between January 2019 and January 2020 in department of Pediatric Surgery at a large institution in India. Methods and Material: Random groups included surgery with and without intramuscular injection of testosterone, respectively. Patients were evaluated pre testosterone therapy for: 1) stretched penile length (SPL), 2) glans circumference at the base. And postoperatively for: 1) reoperation rate, 2) complications. The surgical outcome was compared among the two groups on the basis of cosmesis and postoperative complication rate. Results: A total of 42 patients (21 in each group) matched the eligibility criteria and were recruited in the study. Overall 85% of Group 2 patients showed an increased SPL of approximately 1.15cm. As compared to Group 1, Group 2 performed well in terms of reduced complications, increased SPL and glans circumference at base. Conclusions: Overall, study findings showed better functional outcomes with use of preoperative testosterone treatment and reduced complications. A follow-up study is planned to explore the longterm surgical outcomes of these surgical repairs of preoperative testosterone therapy.

Keywords: Hypospadias; Testosterone; Treatment; Genital Organs; Male.