Background: Seroma formation is commonestc omplication incidence following MRM varying from 15% to 85%. Identifcation of patients
prone to develop seroma helps in early detection and adequate management of seroma thus decreasing its morbidity.

Aims: To analyse impact of age, Body mass index, weight of mastectomy specimen, drain volume, serum albumin, no. of lymph node
& neoadjuvant chemotherapy on seroma formation.

Design: Prospective observational study.Materials and methods: All Patients admitted with Carcinoma breast in Department of Surgery in KIMS, and undergoing MRM included in study.relevant clinical details noted. Patients followed up to look for seroma and its associatin with various factors mentioned above was calculated. Statistical analysis used t- test, z test and chi-square test. p- value < 0.05 was considered significant

Results: Study demonstrated association betweenseroma formation and age> 45 yrs, BMI more than 22.9, weight of specimen >750gm, post operative day1 drain output >120ml, total drain output >600 ml.

Conclusion: we concluded that higher incidence of seroma is anticipated in an elderly obese women with mastectomy specimen weighing >750gm especially if her post operative day 1 drain output is >120 ml and total drain output >600ml.these patients require more frequent follow up for early detection of seroma and its aspiration so as to prevent its complications. Serum albumin level, staging of tumour, number lymph nodes dissected, primary mode of treatment does not contribute for seroma formation.

Keywords: Carcinoma breast; MRM; Seroma; Factors