Context: For decades, there has been a discussion, whether thyroid disorders could cause gallstone disease. These explanations include the known linkbetween thyroid failure and disturbances of lipid metabolism 1 that may consecutively lead to a change of the composition of the bile.A population-based comparative study was performed to determine the
association between thyroid profile and gall stone diseases.

Aims: To know the association between thyroid function change and gall stone formation.

Settings and Design: This is a tertiary care hospital done study descriptive observational study.

Methods and Material: This study was conducted in a tertiary care hospital of north Karnataka .The study duration was January 2018 to December 2018. A total of 1004 patients with gastrointestinal problems and Gallstone were selected randomly for the study. Statistical analysis used: Statistical analysis was done using ratios and percentage.Comparative results were obtained using two group which were compared and calculated using independent t test for
the TSH levels and T4 levels.

Results: There was no difference in the median values of S-TSH (3.06, range 0.27–4.2 vs. 2.8, range 0.28–7.40ulU/ml) and S-T4 (13, range 5.5–13.0 vs. 13.0, range 5.5.–13 ug/dl) between the groups .The
prevalence of subclinical (S-TSH > 4.2ulU/ml;) hypothyroidism in women was 24% in Gallstone disease group and 2.3 than in the control group and in men 24% and 2% (total 5.5%) in the Gallstone disease group than in control group, respectively.

Conclusions: There is an association between change in thyroid function with gallstone disease.
 

Keywords: Cholelithiasis; Thyroid profile; Subclinical hypothyroidism.