Introduction: Pancreatitis is inflammatory process in which the pancreatic enzymes digest the gland. The pancreas sometimes heals without any impairment of function or any morphologic changes. This process is known as acute pancreatitis. Dealing with the clinical course of Acute Pancreatitis (AP) and management of acute pancreatitis are complicated by limited understanding of pathogenesis and multi-causality of the disease, uncertainties to predict outcome and a few effective treatment modalities. Thus, this study was undertaken at Dept of Gen Surgery, at DY Patil Medical College and Research Centre, Pimpri, Pune to study the the various etiological factors of causing pancreatitis, mode of onset of disease and to study the clinical presentations of pancreatitis and its management. Methodology: Total 50 patients were included in this study since 2017 to 2019, who got admitted in Dept of Gen Surgery at Dypmch, Pimpri, Pune. Cases were studied according to clinical history and physical findings and investigations. Treatment was given according to the severity of pancreatitis with either conservative or surgical method or interventional radiological prodcedure. Patients were followed up for 6 months to look for any recurrence or complications. Results: Total 72% pts were males, 28% were females in the study group. Alcohol was most common etiological factor 31 (62%) for pancreatitis followed by history of obstructive jaundice in 8 (16%). Abdominal pain (100%) and vomiting (74%) were the most common modes of presentation. Ascitis (17) and acute pseudocysts (10) were common complications. As severity of pancreatitis increases blood sugar level increases due to reduced secretion of insulin from pancreas after inflammation and it was statistically highly significant (Spearman’s rho = 0.638 p = 0.00), similarly severity of pancreatitis shows positive correlation with enzyme lipase due to release of lipase enzyme form pancreas after inflammation (Spearman’s rho = 0.557 p = 0.00). 42 (84%) subjects were managed conservatively only with IV fluids, antibiotic, antisecretory drugs, (somatostatin analog) 3 (6%) with CT guided percutaneous drainage while remaining treated as per etiology of pancreatitis along with medical management. Conclusion: Acute pancreatitis was a common cause of acute abdomen and alcohol and gallstones were most common causes. Once the final diagnosis is made, along with clinical knowledge one should simultaneously concentrate on laboratory or imaging investigation to find out the underlying etiology and managing the condition by predicting its complications. The management of acute pancreatitis is mostly supportive. Early enteral nutrition in a course of disease modifies the inflammatory response and improves patient outcome by reducing infective complications of the disease. Antibiotics should be used cautiously as prophylactic antibiotics might not be benificial in preventing infective complications of acute pancreatitis.

Keywords: Pancreatitis; Enzymes; Acute Pancreatitis (AP).