The study aimed to assess the knowledge of Nursing students before administering a structured teaching program on the prevention of Hepatitis-B and to Administer a structured steaching program on the prevention of Hepatitis-B.

In this study, a descriptive research approach was used with, one group pre-test post-test quasi-experimental research design. Non-probability purposive sampling technique was used to select the participants (n=60). A self-structured questionnaire was administered as a tool and the collected data was analyzed. The study result has shown that among 60 students, in the pretest knowledge score, 12 (20%) were having in adequate knowledge, 43 (71.7%) were having moderate knowledge, and only 5 (8.3%) students were having adequate knowledge. Where as in post-test majority i.e. 38 (63.4%) were having adequate knowledge, 20 (33.3%) were having moderate and only 2 (3.3%) students were having inadequate knowledge. This indicates that the post-test knowledge score is greater than the pre-test knowledge score Hence the difference between the pre-test and post-test overall knowledge score was 57.46%. So the results of the study show the difference between the pre-test and post-test knowledge scores of the students regarding the prevention of Hepatitis-B.