Context: Cervical cancer is the second leading malignancy in the women occurring worldwide. Researches based on nuclear morphometry on cervicovaginal smears are very much sparse; hence we have taken up this study. Aims: To valuate the role of nuclear morphometric parameters (nuclear radius and area) in differentiation of premalignant lesions of cervix. Settings and Design: Retrospective analysis of nuclear morphometric parameters in cervical smears of 40 cases. Methods and Material: Retrospective analysis of nuclear morphometric parameters in 40 cervical smears (20- LSIL and 20- HSIL) done at Government Kilpauk Medical College. Statistical analysis used: Independent sample t test was used for comparing radius and nuclear area in LSIL and HSIL lesions. Results: There was an appreciable difference in the area of nucleus among the premalignant lesions. The mean nuclear area in LSIL was 109 ± 7.446 um2 and HSIL was 132.48 ± 11.388 um2. Radius of the nucleus also showed appreciable difference in LSIL and HSIL cases included in our study. The mean nuclear radius in LSIL lesions was 3.78 ± 0.25 um and in HSIL lesions was 4.37 ± 0.34 um. Conclusions: Nuclear morphometry is henceforth an useful and dependable investigative tool in the differentiation of premalignant cervical lesions.

Keywords: Nuclear morphometry; LSIL,HSIL.