Introduction: Intracranial cysts are often seen in our daily routine practice. Most of the patients present with symptoms of raised intracranial pressure manifested as headache and vomitings. Most of these are benign in origin with defects in maldevelopment. Histopathological examination plays a major role in the diagnosis of these cases. We have presented a spectrum of lesions in our study period with emphasis on their origin, morphological features and differential diagnosis. Materials and methods: A total of 11 cystic lesions were included in our study. Cystic degeneration of tumors and infective cysts were excluded from our study. Processing was done. Histopatholy slides were made and examined. Immunohistochemistry (IHC) was done wherever required. Results: The lesions included epidermoid, dermoid, neuroenteric, colloid, arachnoid and rathke cleft cysts. Cysts of the neurospinal axis i.e Rathke cleft cyst, colloid cyst and neurenteric cyst had almost identical histological features and the site of the lesion played an important role in the diagnosis of these lesions. Conclusion: Incranial cysts should be diagnosed in correlation with clinical features and imaging findings. These benign lesions can thus be managed appropriately sometimes in aconservative manner also. Histopathological diagnosis thus plays a major role in these intracranial cystic lesions.

Keywords: Incranial cysts; Morphological Spectrum; Histopathological diagnosis; Immunohistochemistry (IHC).