Introduction: Cancer is the major health issue now days with a burden accounting for almost one in every four deaths. Gastrointestinal tract (GIT) is the most commonly involved system in the human body. Adenocarcinomas are more common among intestinal tumors. However benign tumors are more common than the malignant tumors. Gastrointestinal (GI) cancers constitutes 20% of estimated new carcinoma cases and about 15% of estimated death worldwide. Aim: To study the histomorphology of various gastrointestinal lesions. Materials and methods: It was a retrospective study for 4 years. All the biopsies submitted to Department of pathology, SIMS, Shivamogga for histological evaluation during the study period. Altogether 89 GI specimens were fixed in 10% formalin and processed in semi automatic tissue processor. Routine hematoxylin and eosin stain and special stains were done. Results: Total number of cases were 11,000. Among which 89 cases (0.8%) were GIT specimens, both neoplastic and nonneoplastic. Neoplastic lesions constituted 45 cases (50.6%). Non neoplastic lesions constituted 44 cases (49.4%) which includes both inflammatory and non inflammatory lesions. Conclusion: GI lesions constitutes about 0.8% of all the lesions. Most common neoplastic lesion of oesophagus was squamous cell carcinoma where as adenocarcinoma was most common gastric and intestinal neoplastic lesion.

Keywords: Squamous Cell Carcinoma; Gastrointestinal Lesions; Adenocarcinoma.