Background: Upper gastro intestinal (GI) endoscopy is an established mode of investigation and treatment of a wide range of upper gastro intestinal disorders, such as dysphasia, upper GI bleeding, persistent dyspepsia, heartburn, chronic acid reflux and in the surveillance of Barrett’s esophagus, gastric ulcer and duodenal ulcer. Upper gastrointestinal tract is a common site for neoplasm’s especially malignant tumors. Worldwide carcinoma stomach is the second most common cancer and carcinoma esophagus is the sixth leading cause of death. Aims & Objectives: To analyze the histopathological spectrum of diseases in upper GI tract, estimate the incidence of H. Pylori associated chronic gastritis, incidence of malignancy and to correlate clinical features with histopathological diagnosis. Materials and Methods: The present study was conducted in the Department of Pathology, MVJ Medical College and Research Institute, Hoskote over a period 2 years from September 2012 to August 2014. Total of 150 cases who underwent Upper GI Endoscopic Biopsy (esophageal, gastric, and duodenum (1st part) lesions) were studied. Results: Out of the 150 upper GI endoscopic biopsies, 47 (31.3%) were from the esophagus, 95 (63.3%) from stomach and 8 (5.3%) from duodenum. There were 87 male patients and 63 female patients making the male: female ratio of 1.4:1. The highest number of biopsies was done in patients between 41 to 50 years (25.3%). Dysphagia (38.6%) is the commonest presentation with esophageal lesions. Dyspepsia (61.3%) & pain abdomen (38%) were the commonest presentation in patients with gastric lesions. Out of 47 esophageal biopsies 28 (59.2%) were squamous cell carcinoma followed by chronic esophagitis 7 (14.8%). Majority of cases of carcinoma esophagus were in the middle 1/3rd of the esophagus, histologically these proved to be squamous cell carcinoma & adenosquamous carcinoma. Only 2 cases of adenocarcinoma were obtained and these were in the lower 1/3rd of the esophagus. Out of 95 cases of gastric biopsies 79 (83.1%) were Chronic gastritis, followed by 6 (6.25%) were tubular adenocarcinomas. Antrum was most common site of involvement. Among 79 cases of chronic gastritis 50 (63.2%) cases are positive for H pylori and 29 (36.7%) cases are negative for H pylori. Out of 8 cases of duodenal biopsies, chronic duodenitis was the comment lesion. Conclusion: Endoscopic biopsy provides an excellent opportunity for the clinician and histopathologist to study the morphology of the lesion using minimal tissue obtained by an endoscope, also it obviates laparotomies and excision biopsies.

Keywords: Duodenum; Esophagus; Stomach; Upper gastrointestinal Endoscopic Biopsy.