Context: The plethora of pathologies makes diagnosis of dermal lesions challenging. Though, benign lesions are common, malignant conditions need to be ruled out. Clinical and radiological modalities result in inconclusive diagnosis due to overlapping features. Aims: The objectives of the present study are to collocate and organize dermal lesions based on anatomical location and distribution. We also highlight light microscopic features of these dermal lesions. Methods and Material: All cases clinically presenting with a dermal lesions were collected from histopathology archives. Relevant clinical details and histopathological slides were retrieved. The diagnosis was confirmed by review of the slides. Results: Out of 125 cases, only eight cases constituted pathologies with intermediate and/or malignant behavior. Non-neoplastic pathologies such as calcinosis cutis, ganglion cyst, keloid too were encountered. Lipoma accounting for 49.6% cases was the most common pathology. Most malignant lesions were located on extremities and were seen in elderly. Conclusions: It is prudent to consider even non-neoplastic lesions in differentials of dermal lesions. Age and location among other clinical details help in listing the differentials. Adequate sampling and recognisition of characteristic histological pattern helps in accurate pathological diagnosis.

Keywords: Dermal Lesions; Soft Tissue Tumors; Histopathology.