Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous mesenchymal tumor of intermediate malignancy. It has progressive but destructive growth pattern with propensity for focal recurrence and rare metastasis. Studies on fine needle aspiration (FNA) of DFSP are extremely rare. We present a case of primary DFSPFibrosarcoma variant over left lateral leg in a 60 year old male, which was diagnosed on FNA. An accurate cytological diagnosis is crucial in establishing the adequate therapeutic approach, avoiding mutilating surgery. Correct sub typing of DFSP in FNA smears can be difficult due to its morphological overlapping with other spindle cell lesions occurring in the skin and soft tissue. The combination of characteristic morphological features of DFSP with clinical information is crucial to establish a correct diagnosis of such rare tumor. The goal of this report is to emphasize the role of FNA in early and accurate diagnosis in spite of many overlapping features.

Keywords: Dermatofibrosarcoma Protuberans (DFSP); FNA; Leg; Soft Tissue Sarcoma.