Background: Pesticides are a very important group of environmental pollutants used in intensive agriculture for protection against diseases and pests. Pesticides are the some of the deadliest poison produced by human beings, hence present a health hazards in long term exposure even at low levels. Neurotoxicity is major consequence of pesticide effect. Objectives: To study the hematological parameters – haematocrit (Hct) and absolute erythrocyte count (AEC) and biochemical parameters serum glutamate oxaloacetate transaminase (SGOT) in fish Channa punctatus exposed under different concentrations of Metasystox pesticide. Materials and Methods: The fishes collected from river Gomti, at Lucknow were brought to the biochemical laboratory in the plastic bags for processing of experimental study. This study was demonstrated in fish Channa punctatus, which were exposed 24 to 96 hours to four different concentrations of Metasystox pesticide. Analysis of haematocrit (Hct) and absolute erythrocyte count had been done as pathological parameters and serum glutamate oxaloacetate transaminase (SGOT) as biochemical parameter to know the adverse effect of the pesticide. Results and Conclusion: Significant decrease in absolute erythrocyte count was noticed in fish channa punctatus at all concentrations and the time intervals. The results obtained on hematocrit of the fish channa punctatus were also remarkable; it was fall in level at all concentrations and time intervals. Regarding to biochemical parameter, significant increase in aspartate transaminase enzyme levels were observed in Metasystox pesticide exposed fishes. These results concluded that changes in pathological and biochemical parameters are the adverse effect of the Metasystox pesticide. Therefore it is suggested that pesticide sprayers have to take all the safeguard regarding protection from Metasystox pesticide.

Keywords: Metasystox; Hematocrit; Absolute Erythrocyte Count; Aspartate Transaminase; Toxicity.