Background: Chronic kidney disease (CKD) is associated with variety of hematological and biochemical abnormalities. The present study aimed to assess the hematological and biochemical parameters of patients with CKD and to compare the results to those of a control population. Material and Methods: This was a prospective Case control study sectional study included patients of age >16 years, diagnosed with CKD, and serumcreatinine level >1.5 mg/dL. Age-sex matched healthy volunteers were taken as control. Hematological investigations and biochemical tests were compared between CKD and control group. All statistical analyses were performed using SPSS software (version 23). Results: A total of 70 patients with CKD and 62 control participants were enrolled. Hematological parameters including hemoglobin, packed cell volume, mean cell hemoglobin, mean corpuscular hemoglobin concentration, and platelet count were significantly reduced in CKD group compared to control group. White blood cell indices including total leucocyte count, neutrophils, lymphocytes, and monocytes were significantly decreased in CKD group than control group. All the biochemical parameters including serum creatinine, pre-urea all the biochemical parameters including serum creatinine, urea, potassium and phosphorous were significantly increased in CKD group comopared to controls whereas sodium was significantly decreased in CKD group as in comparision to controls, sodium, potassium, and phosphorous were significantly increased in CKD group compared to controls.. Conclusion: Patients with CKD showed a specific profile of hematologicalandbiochemical parameters. A good understanding of the differences in our cohort with those in the general population might aid in the clinical follow-up of patients with CKD.

Keywords: Hemodialysis, Rbc Indices, Platelet Count, Total Leucocyte Cout.