Aims: To analyze clinical parameters, histomorphological features of Nasopharyngeal angiofibroma.Materials and Methods: The present study is a retrospective and prospective study conducted for 6 ½ yrs. durationin a total of 7222 head and neck cases operated, out of which 78 cases were diagnosed as juvenile nasopharyngeal
angiofibroma. All patients were evaluated with routine lab investigations and all clinical features noted. Thepatients were investigated with x-ray and CT head and neck.

Results: Incidence of juvenile nasopharyngeal angiofibroma was 1.08% of head and neck tumours. In all the cases were male incidence was high in second decade.The tumour tissue was lined by pseudostratified epithelium in 52 cases (66.66%) followed by squamous (metaplastic) in 14 cases (17.94%). Remaining 12 cases showed ulceration and
granulation tissue.The calibre of vascular channels was studied in detail showed 36 cases (48.71%) with small thin nonmacular followed by 29 cases which showed large thin nonmuscular vessels. Stroma was composed of plump cells, edematous and fibrous components. Out of 78 cases, 45 cases (57.69%) were composed of mixed pattern with
any of the two or all three components. Secondary changes like thrombus, hemorrhage and necrosis were observed in 17 cases.25 sections rich in stromal cells were selected and subjected to immunohistochemistry-C-kit. Out of 25 cases 23(92%) showed high to moderate immunoexpression and 2 cases (8%) showed weak positivity. C-kit expression was seen in all cases of nasopharyngeal angiofibroma with 92% of high expression.

Conclusions: Study showed new hope and promise of application of C-kit expression in nasopharyngeal angiofibromas to evaluate the response to imatinib therapy.

Keywords: Nasopharngeal; Angiofibroma and C-Kit.