The meticulous diagnoses of the disease in Ayurveda completely rely on five means of diagnosis (nidanapanchaka), out of that lakshana (clinical features) plays an important role. These are manifested as the result of Gunata (qualitative) and Dravyata (quantitative) vitiation of various factors like dosha, dushya, srotas, agni, prakruti, bala and kala etc, involved in the process of samprapti (pathogenesis). Clinical features are occurred in different stages of samprapti, in doshadushyasamurchana avasta called as poorvarupa (premonitory clinical feature) and some manifested after the completion of doshadushyasamurchana called as roopa (clinical features) among these some are unique and specific to particular disease and these are called as pratyatma lakshana (cardinal features), for e.g.  dehamanasantapa of jwara, malasarana of atisara and netratwakpanduta of pandu etc, understanding and diagnosis of srotogatavyadhis (systemic diseases) remains a challenging even after knowing the clinical features, because a single clinical feature of particular disease occur in more than one disease of same srotas or other srotas, but pratyatma lakshanas are unique to particular disease so it carries a great value in the accurate and final diagnosis of the disease along with other common features manifested as poorvarupa and roopa of srotogatavyadhis. By considering uniqueness of pratyatma lakshana the present work is taken into consideration.

Keywords: Pratyatma Lakshana; Roopa; Poorvarupa; Doshadushyasamurchana; Clinical Features; Diagnosis.