Acute pancreatitis is sudden inflammation of the pancreas that may be mild or life threatening but usually subsides. Acute Pancreatitis is an acute inflammatory process of the pancreas with varying involvement of regional tissues or remote organ systems. Gallstones and alcohol abuse are the main causes of acute pancreatitis. Severe abdominal pain is the predominant symptom. Blood tests and imaging tests, such as computed tomography, help the doctor make the diagnosis. Whether mild, moderate, or severe, acute pancreatitis usually requires hospitalization. Here case reported with a history of tooth removal and given analgesic – NSAIDS – Diclofenac post intake patient develop severe pain abdomen, vomiting and restlessness. Patient being hospitalized for the same and regular investigation done suggestive of Acute Pancreatitis. Patient recovered as per standard treatment given.

Keywords: Acute Pancreatitis; Diclofenac; Serum Amylase; Serum Lipase; NPO.