This review article addressed the emphasis on pain in people living with HIV/AIDS (PLWHA) through a literature overview. There was a high prevalence of pain in PLWHA, associated with psychiatric comorbidities and post-traumatic stress disorder, thus adversely impacting quality of life. Treatments including anti-retroviral therapy, analgesic therapy when provided along a multidimensional approach, together with alternative therapies would combat pain in PLWHA. The evidence presented in this study included assessment studies that reported about pain in PLWHA and treatments for pain in PLWHA. Despite the under-reporting of HIV/AIDS in palliative care literature, researchers and clinicians need to realize the under-estimation and under-treatment of pain in PLWHA along a multidisciplinary biopsychosocial model to improve their health-related quality of life.

Keywords: Palliative Immunology;  Immuno-anesthesiology; Immuno-analgesia; HIV/AIDS.