Background: Patients who have PCO with significantly reduced visual acuity need posterior capsulotomy to improve vision. Nd:YAG laser for posterior capsulotomy is a widely used, safe, noninvasive, and effective procedure with minimal complications. The aim of this study is to estimate mean energy levels for Nd:YAG laser capsulotomy in various subtypes of PCO (membranous, fibrous,and fibro-membranous). Setting And Design: This is a prospective comparative study at a rural based, tertiary level hospital. Methods And Materials: This study has been performed at our institute between September 2013 and September 2015 after taking clearance from the ethics committee. 100 eyes of 100 patients with PCO were considered for Nd:YAG laser capsulotomy after minimum period of 6 months following uncomplicated extracapsular cataract extraction.Statistical analysis was done by the unpaired t-test using SPSS software. Results: In our study, the mean initial and mean summated laser energy levels were different for different subtypes of PCO. There was a significant difference in mean initial laser energy levels for different subtypes of PCO (p<0.001). Mean initial laser energy level was minimum for membranous PCO (1.4 mJ) followed by fibro-membranous PCO (2.2 mJ) and maximum for fibrous PCO (3.2 mJ), whereas the mean summated energy level for membranous was 25.22 mJ, for fibrous 51.48 mJ and for fibro-membranous was 70.08 mJ. The mean summated laser energy level was maximum