Purpose: The main objective of the present research investigation is to formulate transdermal patches of famotidine using different polymers. Famotidineis a H2 blockers.

Methods: The transdermal patches of famotidine were prepared employing different concentrations of HPMC, and Ethyl cellulose.

Results and Discussion: All patches exhibited satisfactory characteristics regarding integrity, flexibility, dispersion of drug, and other quality control parameters. In the invitro release studies of transdermal patches, formulation F10 showed the prolonged release of drug (88%) for 12 h, which indicates the maximum availability of the drug. The kinetic studies were carried out and it was found that all the formulations follow zero order and the release mechanism of drugs was found to be diffusion rate limited, Non-Fickian mechanism which was confirmed by Korsmeyer–Peppas model.

Conclusion: This suggests the transdermal application of Famotidine holds the promised controlled release of the drug for an extended period of time.