Lower limb Defects were encountered by the plastic surgeons most commonly in the practise. The management and reconstruction of complex lower limb defects needs a multidisciplinary team approach. A multidisciplinary team has successfully adopted advanced reconstructive methods combined with modalities from regenerative medicine to enhance the results of difficult reconstruction. These procedures, known as "Hybrid reconstruction ladder," combine conventional reconstruction techniques with regenerative medicine applications. This review article provides a summary of the benefits of using a hybrid reconstruction ladder to create a healthy wound bed and reconstruction in a case of Lower limb defect reconstruction.