Abstract Genetic diseases may seem esoteric to nurses, but knowledge of genetic disorder will help nurses to recognition and assessment of possible genetic disease, to obtain comprehensive family histories, identify high risk for developing malformation, help people to make informed decisions about and understand the results of their genetic/genomic tests and therapies, and refer at-risk people to appropriate health care professionals and agencies for specialized care. Nurses should have independent knowledge on genetics and disorders rather than depending on medicine professionals. Controls of Occupational hazards are another key component in prevention of malformations. Occupational nurses can advice to clients to avoide of exposure to teratogens (e.g. alcohol, recreational drugs, and certain chemicals and infectious agents) during pregnancy. Nurse administrator can design a policy Guidelines to facilitate the integration of various departmental staff to provide comprehensive nursing Care package for patients and family with congenital malformation. Keywords: Role of Nurse; Prevention; Congenital Malformation.