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Effect of Ondansetron on QTc Interval during Sevoflurane Anaesthesia: A prospective Randomized Double-Blind Study
Original Article

Aim and objectives: Serious drug interactions are amongst the common problems encountered
by the anaesthesiologists in their practice that compells them to understand the effects of
individual drugs and their combinations. One such drug interaction is the effect of sevoflurane
and ondonsetron on QT interval when administered individually and also when combined
together.The aim of the study is toevaluate the effects of Ondansetron and Sevoflurane and
theirpossible synergistic effectson QT interval. The effects on QT interval were observed
whenOndansetron was administered on patients undergoing Sevoflurane anesthesia using
corrected QT interval (QTc) by Bazett’s formula.
Methodology: Our study was a prospective randomized double blinded study which was
done to evaluate QTc interval in 150 patients, aged between 20-60 years. QT interval was
corrected by using Bazett’s formulato the heart rateand are noted at various interval period
such as base line(Preoperative period), 10min, 15min, and 20 mins after the administration of
ondansetron using 5 lead ECG in Lead II.
Results: There was significant prolongation of QTc interval in Sevoflurane + ondansetron
group (477.92 ± 11.44) when compared with placebo (448.93 ± 8.21) with p value of <0.00001.
Conclusion: Ondansetron when administered with sevoflurane significantly prolonged
theQTc intervalthat was not significant enough to produce arrhythmias. Though this
combination seems to be safe, one must consider caution when administering these drugs to
patients with long QT syndrome or any arrhythmia along with continuous ECG monitoring.Keywords: Ondansetron; Sevoflurane; QT interval.