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Abstract

 Chronic lower limb ulcer is a wound that shows no tendency to heal after 3 months of appropriate treatment or is still not fully healed at 12 months. There are various causes of non-healing ulcer which include vascular insufficiency, diabetic ulcer and various infections. One such cause is Pyoderma gangrenosum, which is a chronic, relapsing, ulcerative inflammatory neutrophilic dermatosis with distinctive clinical manifestations. It shows a strong association with systemic diseases like inflammatory bowel disease, seronegative arthritis and lymphoproliferative disorders. No specific investigations are available for the diagnosis which mainly depends on clinical features. Corticosteroids and immunosuppressant therapy are mainstays in treatment. Here, we present a case of pyoderma gangrenosum in a 55 year old female over lower limb, treated with cyclophosphamide pulse therapy and showed good improvement.

Keywords: Pyoderma gangrenosum (PG); neutrophilic dermatoses; non healing ulcer.

Corresponding Author : Nair Pragya A, Professor & Head, Dept of Dermatology, Venereology & Leprosy, Pramukhswami Medical College, Shree Krishna Hospital, Karamsad, Anand, Gujarat 388325, India.