Niosomes are microscopic lamellar structure formed on admixture of non-ionic surfactant of the alkyl or dialkyl poly glycerol ether class and cholesterol with subsequent hydration in aqueous medium. Types: 1) SUV-Small Unilamellar Vesicle, 2) MLV-Multi Lamellar Vesicles, 3) LUV-Large Unilamellar Vesicles. Niosomes are designed to concentrate the drug to the tissue of interest as a result drug is localized on the targeted site. Hence, healthy tissues are not affected by the drug. The properties of the vesicles can be changed by varying the composition of vesicles, size, lamellarity, tapped volume, surface change and concentration.