Background: The ability to diagnose and treat subclinical hypothyroidism in diabetic patients may greatly enhance the quality of life. The treatment of hypothyroidism helps in better control of other associated co-morbidities. Therefore, in present study association between thyroid dysfunction and Diabetes was assessed by correlating Fasting plasma glucose and Thyroid profile.

Materials and Methods: A total of 40 subjects attending the OPD who were diagnosed for diabetes were recruited.40 normal age and sex matched participants were recruited as controls. Informed written consent was obtained from all the participants. Fasting plasma glucose was estimated by glucose oxidase method and TSH, T 3 and T4 by enzyme-immunoassay (ELISA) method using commercially available kit. Subjects grouped as normal with TSH level0.39-6.16mIU/l, T3 levels 52-185ng/dl and T4level as 5.0-15.0µg/dl. Lower T 3 and T4 with high TSH is considered as Hypothyroidism and higher levels of T3, T4 with low TSH is considered as hyperthyroidism.The data was analysed using SPSS version 20. Unpaired t test and Pearson’s correlation was performed to find the significant differences between the groups and their correlation. P<0.05 was considered as statistically significant.

Results: The Chi-square test was used to find the association between diabetes and thyroid dysfunction showed significant association (p<0.05) between Diabetes and thyroid dysfunction. On comparison, showed no difference in the sugar levels according to dysfunction status(p<0.05).

Conclusion: A routine assessment of thyroid hormone levels in diabetics is necessary, particularly with subclinical thyroid hormones level.

Keywords: Fasting Plasma Glucose Level; Glucose Oxidase Method; TSH; T3; T4; Enzymelinked Immunoassay.