Lacosamide (LCM), a third generation antiepileptic drug, is used as
an adjunctive therapy or monotherapy in focal seizures. It enhances slow inactivation of voltage gated sodium channels and acts on collapsin-response mediator protein-2. Toxic ingestion of lacosamide has been documented and patients developed severe neurological and cardiac manifestation and few cases were fatal. Currently, there isno antidote for lacosamide poisoning. The poisoned patients are managed conservatively. Inj. sodium bicarbonate therapy was given in few cases to correct for cardiac arrhythmia. In many reported cases multiple tablets were consumed for poisoning except one case report documented isolated ingestion of lacosamide. We report a case
of acute overdose of isolated lacosamide poisoning who was brought to our emergency department in an unresponsive state with a history of seizure.
Keywords: Antiepileptics poisoning; Lacosamide poisoning; Sodium
bicarbonate therapy; Torsades de pointes.