Objectives: To compare the efficacy and safety of oral nifedipine and parenteral isoxsuprine in suppression of preterm labour. Methods: This is a prospective trial. 100 antenatal cases with 28- 36 weeks of gestation with threatened or early preterm labour were selected and divided in 2 groups. Group A received oral nifedipine, while group B received parenteral isoxsuprine. Outcome was analyzed with respect to prolongation of pregnancy, maternal and fetal side effects. Conclusion: Nifedipine is preferred tocolytic agent than isoxsuprine in arrest of early preterm labour with lesser maternal side effects.

Keywords: Preterm Labour; Nifedipine; Isoxsuprine.