Abstract Maternal infection acquired during pregnancy and perinatal period can adversely affect pregnancy outcome as well as morbidity of the newborn. It could result in stillbirth or associated with many congenital anomalies, specific for the type of infection. The organism may be bacterial, viral and protozoal. Early detection and prompt institution of therapy wherever available can prevent morbidity and mortality of the newborn. Vaccination is available against many such infections like varicella, rubella, HepatitisB which has helped in reduction of such infection. CMV against which no vaccination is available yet, is emerging as the most common infection in this category. The scope of this article will include an overview of such injections followed by salient features about CMV infection.