Introduction: Currently antibiotic resistance in bacterial populations is one of the greatest challenges to the effective management of infections. Infections caused by Pseudomonas aeruginosa are frequently life threatening & difficult to treat as it exhibits intrinsically high resistance to many antimicrobials & the development of increased, particularly multi-drug resistance in health care settings. Objective: The present study was done to determine the drug sensitivity pattern of Pseudomonas aeruginosa from various clinical specimens in our set up. Materials and Method: This study was conducted during October 2015 to May 2016. A total of 376 strains of Pseudomonas aeruginosa were isolated from various clinical specimens. Pseudomonas aeruginosa was identified by using standard microbiological techniques. Antimicrobial susceptibility patterns of all the isolates were carried out by Kirby- Bauer disk diffusion method as per CLSI guidelines. Result: A total 376 strains of Pseudomonas aeruginosa were isolated of which 267 (71%) were from indoor & 109 (29%) were from outdoor patients. Of the 376 isolates 206 were from males & 170 were from females. Majority of isolates of Pseudomonas aeruginosa were obtained from specimens of pus. Majority of the strains showed low level of susceptibility to Ceftazidime (38%), Ofloxacin (40.4%), Ciprofloxacin (42.1%), Piperacillin (47.7%) & Gentamicin (51%). We got good sensitivity with Tobramycin (82.1%) & with Amikacin (78.3%). All isolates were susceptible to Imipenem (100%). Conclusion: The result of our study suggests the occurrence of resistant strains of Pseudomonas aeruginosa. Periodic susceptibility testing should be carried out over a period of two to three years to detect the resistance trends & judicious, rational treatment regimen prescription should be followed by physician.

Keywords: Antibiotic Susceptibility Pattern; Pseudomonas aeruginosa.