Purpose: To determine the prevalence of dry eye in ophthalmology out patients At a tertiary carehospital and its possible association with various clinico epidemiological factors. Patients and Methods: This was a hospital based cross sectional study involving 390 patients who visited ophthalmology OPD in a tertiary care hospital. Patients who are aged more than 40 years irrespective of their dry eye related complaints. Tear film break up time was used as an indicator for the diagnosis of Dry eye disease. The study span was of 10 months. Results: Overall prevalence of DED was 51.6% among the patients. The prevalence of DED was more among elderly population as well as among patients who are having diabetes and hypertension with prevalence of 59% and 49% respectively. Females constituted more in number as well as they had higher prevalence of DED 55.8%. Burning sensation and watering was present in 39% and 32% of DED patients respectively. Conclusion: This study reflects a major burden of DED among the routine out patients. We observed various contributing factors for dry eye such as age, female gender, outdoor jobs, Tobacco consumption, Diabetes Mellitus, Hypertension, Meibomian gland disease, antiglaucoma medications and contact lens use to name a few. There is need to educate general public regarding the awareness and sensitivity toward the symptoms of DED. Further studies need to be undertaken