Background: The present study aimed to study the role of citicoline as an adjuvant to patching in unilateral Amblyopia. Methodology: The study was conducted at atertiary care centred ,during the study period of 1 year on 50 patients presenting with mild to moderate amblyopia. Patients were subjected to detailed history and ocular examination using a slit lamp. Results: 24% patients belonged to the age group of 7-8 years of age. About 52% cases were females. Citicholine with patching therapy was used in 25 cases (36% strabismus cases, 32% anisometropia and 32% combined ) and patching therapy was used in 25 cases ( 32% strabismus , 40% anisometropia and 28% combined ). Conclusion: Though this study has its limitations nonetheless it shows that adding citicoline in addition to patching therapy can significantly influence the visual acuity in amblyopia patients.