Purpose: Our study assesses the impact of injection ranibizumab on patients with wet ARMD. We take into account OCT parameters pre- and post- administration of injection ranibizumab. We then correlate the effects of these parameters with visual outcome in these patients. Methods: This was a prospective study of 40 eyes of 40 patients in DY Patil Hospital, Nerul, Navi Mumbai over a period of 1 year. All patients were treated with monthly intravitreal ranibizumab injections (0.5 mg/0.05 ml) for 3 months. Changes in foveal photoreceptor layer integrity, choroidal neovascular membrane, diameter, thickness, central macular thickness, subretinal fluid assessment was done by spectral domain OCT at every visit and correlated with final visual outcome. Results: It was observed that intravitreal injection ranibizumab has a significant effect on improvement in OCT parameters of these patients. Also, the patients who had significant improvement in OCT had improvement in visual acuity finally. Conclusion: Intravitreal ranibizumab is a good choice of treatment in wet ARMD patients. Improvements in OCT could be correlated with visual improvement in these patients.

Keywords: Age related macular degeneration; Choroidal neo-vascularization; Ranibizumab.