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DOI: http://dx.doi.org/10.21088/jcms.2454.7123.4118.6

Abstract

Aims and Objective: To assess the association of lipoprotein a (Lp a) with coronary artery disease (CAD) in Western Indians. Material and methods: In this single centric, prospective and case control study 200 subjects (100 patients with CAD & 100 healthy volunteer) were enrolled. Fasting blood sample were collected from the antecubital vein of the subjects under sterile conditions. Lipid profile parameters such as total cholesterol (TC), triglyceride (TG), total lipid (TL), low density lipoprotein (LDL), high density lipoprotein (HDL), and very low density lipoprotein cholesterol (VLDL), Lp (a) were measured. Results: The prevalence of cardio-metabolic risk factors was significantly higher in cases as compared to controls (p<0.05). Similarly significantly higher mean lipid levels namely total cholesterol, triglyceride, low density lipoprotein and Lp (a) was observed in CAD patients as compared to their counterparts. Lp (a) levels were well correlated with angiographic severity of the disease and overall incidence of the disease was found to be highest in the greatest quartile of Lp (a). Conclusion: Lp (a) levels are important markers of CAD in Western Indians and could be effectively used to in clinical setting.

 

 

Keywords : Lipoprotein A; Western Indians; Coronary Artery Disease; Lipid Profile. 

Corresponding Author : Pranav Sharma, Professor, Department of Cardiovascular and Thoracic Surgery, UN Mehta Institute of Cardiology and Research Center, New Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat 380016, India.