This article is aimed to inform the readers on the role of exercise therapy in improving quality of life of people with cardiovascular disorders by providing an integrative overview of systematic reviews. There were two systematic reviews on stroke, three on chronic heart failure and two on intermittent claudication found in our search of PubMed database, and most of them reported improvements in physical functioning and bodily pain components of health-related quality of life (HrQoL) in people who were administered supervised aerobic exercise training. This throws light on need for future studies addressing non-operative and pre-/post-operative rehabilitation using exercise and its effect on HrQoL in this population.