Novel risk factors are emerging behind the genesis of atherosclerosis in today’s era of moleculogy. High sensitive CRP is one of the frontiers in this field besides homocysteine, fibrinogen and Lp (a). We report a case of premenopausal lady without conventional risk factors with malignant manifestations of atherosclerosis having only elevated hsCRP to explain the scenario. Being a biomarker behind inflammatory vascular stress, it stands out a promising molecule in today’s atherobiology. Exercise and statins can bring down this inflammatory insult, resulting in a healthy vascular tree.