Omentin-1 is a novel adipokine that is highly expressed in visceral adipose tissue. Omentin-1, has appeared to show cardioprotective nature in several studies. The aim of this study was to review the existing literature from clinical studies on the role played by omentin-1 in the context of cardiovascular disorders. A total of 14 articles were finalized from the 1158 articles that were screened using the search terms “omentin AND cardiovascular disease”. Omentin-1 is found in lower concentrations in diseased individuals (CAD or risk factors of CAD), and the concomitant presence of CAD and metabolic syndrome or diabetes further suppresses omentin-1 concentration indicating that omentin-1 is an important regulatory molecule in pathways key to the development of cardiovascular disease. Omentin -1 was found to have a moderate correlation with inflammatory biomarkers. Omentin-1 levels were found to predict CAD severity even when adjusted for multiple risk factors. Lower levels of omentin-1 were also found to have a five times higher risk of cardiovascular events in patients with heart failure. The main limitations existing in the literature are the lack of well designed prospective cohort studies that explore the utility of omentin-1 in CVD and the inter study variability in the concentration of omentin-1 across several studies. Much translational work needs to be carried out before omentin-1 measurement becomes an important tool in clinical medicine. Keywords: Omentin-1, cardiovascular disease, risk, biomarker, diabetes, metabolic syndrome