This editorial aimed to provide an overview of recent scientific advances in the field of cardiovascular medicine and surgery (CVMS) and implicate evidence-informed role for the Journal of Cardiovascular Medicine and Surgery (JCVMS). Cardiovascular disorders were associated with higher mortality rate; practice-based evidence for perioperative and postoperative antibiotic therapy in cardiac surgery; efficacy of surgical septal myectomy for obstructive hypertrophic cardiomyopathy; role of regenerative medicine and stem cell transplantation in CVMS; professional associations and societies’ guidelines and recommendations for indications for coronary angiography and coronary revascularization surgeries, and diagnostic catheterization. Amidst the emerging scientific developments, there is still a huge demand for establishing evidence, which should be exploited well by JCVMS. 

Keywords: Evidence-Informed Cardiovascular Medicine and Surgery; Cardiothoracic Science; Cardiothoracic Research; Evidence-Based Practice.