Reteplase, a tissue plasminogen activator commonly used as a thrombolytic agent in acute
ST elevated myocardial infarction;howeverits use inprosthetic mechanical valve thrombosis remains controversial. We report a case of mechanical aortic prosthetic valve thrombosis which was successfully treated with reteplase.Being faster acting and more efficacious, tissue plasminogen activators like reteplase and tenecteplase can be attractive and better alternative to the age old streptokinase used conventionally to treat prosthetic valve thrombosis.