Background: Coronary artery disease (CAD) remains the leading cause of death in the industrialized world. Indians also show higher incidence, morbidity and mortality than other ethnic groups.1 Many of these deaths are attributed to the development of arrhythmias during periods of myocardialinfarction.

Objective: To evaluate the incidence and profile of cardiac arrhythmias in acute myocardial infarction in the first 48 hours of hospitalization i.e. periinfarction period and during first week of acute Myocardial infarction.

Methodology: A hospital based cross sectional study was conducted for a period of 2 years from December 2017 to January 2019. 100 Acute myocardial infarction patients admitted to ICCU during this period were included in the study. Patients aged >18 years admitted in the ICCU with acute myocardial infarction were included in the study. Patients with preexisting Cardiac abnormalities such as pervious MI, arrhythmias, cardiomyopathy were excluded from the study.

Results: In our study nearly 48% had anterior wall MI, 26% had inferior wall MI, 10% had Inferolateral MI, 6% had Inferior wall + RV and 10% had Lateral wall and thrombolysis was done in 70% of subjects. In the study 72% had Arrhythmia, majority had arrhythmia at 1st hour (72.2%), majority had spontaneous termination of Arrhythmia (52.8%). Most common Arrhythmia among MI subjects was Sinus bradycardia (25%), followed by VPC (16.7%), 8.3% had 2nd degree heart block.

Conclusion: Ventricular premature contraction was a second most common arrhythmia. However ventricular premature contractions also occurred along with other arrhythmias like first degree heart block, sinus bradycardia, sinus tachycardia, right bundle branch block and ventricular tachycardia. Arrhythmias are common during first 48 hours and plays an significant role in outcome of acute of myocardial infarction.