The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. The red cell sickling and poor oxygen delivery can also cause organ damage. Over a lifetime, SCD can harm a person’s spleen, brain, eyes, lungs, liver, heart, kidneys, penis, joints, bones,or skin. Sickle cells cannot change shape easily, so they tend to burst apart or hemolyze. Normal red blood cells live about 90 to 120 days, but sickle cells last only 10 to 20 days. We present a case of 17­year­old male, a known case of sickle cell disease, admitted in the medical ward with vaso­occlusive crisis. During treatment, he developed high grade fever with sweating and worsening of his condition. Blood investigations, septic screen and serology for Parvovirus B19 revealed that he was parvovirus IgM positive. He was diagnosed as a case of sickle cell disease with aplastic crisis and low reticulocyte count. He recovered after ten day of treatment.

Keywords: Aplastic Crisis; Parvovirus B19; Pancytopenia; Sickle Cell Anaemia.