Glanders and Farcy is a contagious and fatal disease of horses, donkeys and mules caused by infection with gram negative bacteria Burkholderia mallei. The pathogen causes nodules and ulceration of
mucus membrane in upper respiratory tract and lungs. A skin form also known as Farcy, which may be zoonotically importance in human beings. The disease was successfully controlled in UP state by continued sero surveillance at regular interval in each district of UP by National Research Center on Equines, Hisar with the help of veterinarian of department of animal husbandry UP and also adoption of Glanders and Farcy Act, 1899. It is rare disease in humans with cases having occurred in veterinarians and other people working closely with handling of horses and susceptible laboratory animals.

Key words: Glanders and Farcy; B mallei; Horses; Sero surveillance; Veterinarian.