Context: The procedures like laryngoscopy and intubation evoke stress response in patients
undergoing elective surgeries under general anaesthesia.
Aims: To compare and evaluate dexmedetomidine and fentanyl on hemodynamic response
like Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean
Arterial Pressure (MAP) in patients during intubation and extubation.
Settingsand Design: Doubleblinded Randomised Control prospective Study
Materials and Methods: AAfterobtainingethical clearance, 90 patients belonging to American
Society of Anaesthesiologists class I/II, Scheduled for surgeries with duration of approx.
90mins were randomly divided into two groups. Group A received dexmedetomidine 1μg/
kg as loading dose over 10mns prior to induction followed by infusion at 0.5μg/kg/hr until
10mins prior to extubation. Group B received IV Fentanyl 1μg/kg as loading dose over 10mins
prior to induction followed by infusion at 0.5 μg/kg/hr until 10mins prior to extubation.
Exclusion criteria included cardiovascular disease, Obesity >30kg/m2, patients with
anticipated difficult airway, on sedatives, hypnotics and who have allergy to the study drug.
Statistical analysis used: Data analyzed- SPSS22.0 software. Test of significance: Chi-squaretest.
Continuousdata: Mean standard deviation. Testof significance:Independentttest p value:<0.05-
Results: With respect to hemodynamic response during intubation and extubation, Group
A has shown significantly lower HR, SBP, DBP and MAP in comparison to Group B. Postoperative
Visual Analogue Score for first 24hrs was significantly less in Group A compared to
Conclusion: Dexmedetomidine is better and safe alternative to fentanyl in attenuating
hemodynamic response during both intubation and extubation
: G N S Sravanthi1