Back ground and Aims: This study aims to evaluate the effectiveness of intra-articular injection of platelet rich plasma (PRP)in reducing pain and improving physical function, in osteoarthritis. Method: Prospective longitudinal study comprising of 100 patient& divided into 3groups according to Kallgren & Lawrence grading of osteoarthritis of knee and followed up for period of 1 year (january18 to October 19). All patients were treated with intraarticular PRP injection (C-arm guided) in affected knee at 4weeks apart. VAS (Visual analog scale), KOOS (knee injury osteoarthritis outcome score) used for clinical evaluation. Data analyzed using SPSS software 22.0. Result: Outcome were almost similar for grade 1&2 though intensity of pain showed significant improvement
even in grade3(p<0.05). on the basis of VAS SCORE Highly significant improvement in pain in Grade1 and Grade2 osteoarthritis having p value<0.0001 and significant improvement in Grade3 osteoarthritis having p value=0.003(<0.05). On the basis of KOOS SCORE all the parameter like pain symptom, functional daily activity, sport & recreational activity and quality of life highly significant improve in Grade1&2 pvalue<0.0001 and for Grade3 significant improvement in all parameter having p value<0.05. Conclusion: PRP injection is a cost effective, reliable, minimal invasive, no side effect, good efficacy & used
in less equipped setting. And showed clinical as well as functional improvement in VAS score and KOOS score. It is highly significant for grade 1 and 2 and significant for grade 3 osteoarthritis.