In the present study, 100 patients of ASA Grade I and II between age group of 20-65 years of weight range 40-70 kg were included. These 100 patients were divided into 2 equal groups of 50 patients each according to the drugs administered for brachial plexus block. Group A control group received 30 ml of Ropivacaine 0.5% with 0.5 ml of normal saline and Group B patients received 30 ml Ropivacaine 0.5% with Dexmedetomidine 50 μgm 0.5 ml for brachial plexus block. Intravenous infusion line was set up and all patients were monitored throughout intraoperative period and observed for changes in pulse rate, blood pressure, respiration and any untoward effects. It was observed that, the onset of motor and sensory block was significantly quicker in Group B (study group) as compared to Group A (control group). The duration of motor blockade and sensory blockade was significantly longer in Group B patients as compared to Group A patients. The quality of sensory blockade was excellent in Group B patients and satisfactory in Group A patients. The duration of postoperative analgesia was significantly more prolonged in Group B patients as compared to Group A patients. There were no significant changes in mean pulse rate and mean arterial pressure at various time intervals in both groups during intraoperative and postoperative period. There were no dreadful complications in any patients during intraoperative and postoperative period in both groups.