Advertisement!
Author Information Pack
Editorial Board
Submit article
Special Issue
Editor's selection process
Join as Reviewer/Editor
List of Reviewer
Indexing Information
Most popular articles
Purchase Single Articles
Archive
Free Online Access
Current Issue
Recommend this journal to your library
Advertiser
Accepted Articles
Search Articles
Email Alerts
FAQ
Contact Us
Indian Journal of Anesthesia and Analgesia

Volume  7, Issue 1, JAN-FEB 2020, Pages 215-222
 

Original Article

Comparison of the Efficacy of Neuraxial Blockade Analgesic Effect between Intrathecal Clonidine and Tramadol as An Adjuvant with 0.5% Bupivacaine

P Sridhar, VA Sabapathy, R Shankar

1Associate Professor, Department of Anesthesiology, Danalakshmi Srinivasan Medical College and Hospitals, Perambalur, Tamil Nadu 621113, India. 2Professor, Department of Anesthesiology 3Professor, Department of Preventive Medicine, Vinayaka Missions Kirupananda Variyar Medical College and Hoapital, Salem, Tamil Nadu 636308, India.

Choose an option to locate / access this Article:
90 days Access
Check if you have access through your login credentials.        PDF      |
|

Open Access: View PDF

DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7120.29

Abstract

 

Background: A number of adjuvants in the form of opioids analgesics were routinely used intrathecally to prolong the analgesia effect both in the intraoperative and postoperative period. Clonidine and tramadol were the common agents used intrathecally along with bupivacaine for increasing the duration of analgesia. Aim: To assess and compare the neuraxial blockade analgesic effect between intrathecal clonidine and intrathecal tramadol along with 0.5% hyperbaric bupivacaine for lower limb surgeries. Methodology: A prospective double blinded randomized study was conducted for a period of one year at Dhanalakshmi Srinivasan Medical College and Hospital. A total of 100 patients who had been posted for elective lower limb surgery were included
in our study and they were randomized into two groups of 50 each. Group A patients received clonidine hydrochloride 37.5 mcg (0.25 ml) and Group B patients received tramadol 25 mg (0.5 ml) and both the groups received 0.5% hyperbaric bupivacaine hydrochloride (3 ml) along with normal saline. Assessment of pain score was done using VAS scale and the motor blockade was assessed using Bromage motor blockade score and the vital parameters were also assessed along with it. Results: The onset of sensory analgesia was found to be much faster and the duration of sensory analgesia was found to be more prolonged among the group which received clonidine and the pain score which was measured using VAS was higher among the patients who received tramadol and the difference was found to be statistically significant (p < .05). The duration of motor function recovery was almost similar in both the groups and no significant side effects reported between the two groups. Conclusion: Both the groups were effective in producing adequate surgical anesthesia with hemodynamic stability without causing serious adverse events but clonidine group was found to have a faster onset of action with prolonged duration of analgesia.


Keywords : Clonidine; Tramadol; Intrathecal; Analgesia.
Corresponding Author : VA Sabapathy