The primary aim is to compare postoperative analgesia by intraperitoneal infiltration of bupivacaine versus bupivacaine with dexmedetomidine in laparoscopic surgery. The secondary objective to assess postoperative pain relief, rescue analgesic drug requirement and side-effects in both groups. The study was approved by the University’s institutional ethics committee (Reg No. ECR 518/Inst/MH/2014/RR-17) and written informed consent was obtained from all subjects participating in the trial. The  study  was conducted prior to patient enrollment at Bharati Vidyapeeth Medical College institutional ethics committee (REF: BVDUMC/IEC/62, Principal investigator: Hemadip Tavethiya, Date of registration: 7th September, 2018). This  prospective  comparative study enrolled a sample of 52 patients, 26 in each group. Group B received only Bupivacaine intraperitoneally and Group BD received Bupivacaine with adjuvant Dexmedetomidine intraperitoneally. VAS score was seen at 1, 2, 4, 6, 12, 24 hours postsurgery and VAS score > 3 was given IV paracetamol or IV diclofenac sodium as rescue drug. Results: VAS at different time intervals, overall VAS in 24 h was significantly lower (2.34 ± 0.84, 3.65 
± 0.47), total analgesic consumption was low in Group BD than Group B. Conclusion: Intraperitoneal instillation of bupivacaine in combination with dexmedetomidine is superior to bupivacaine alone.