Introduction: Acute hyperglycemia is known to occur during major surgeries, its occurrence even for a brief period may lead to immune suppression. Surgeries which require general anesthesia are more susceptible for stress mediated immune response and intraop rise in blood glucose levels. Drugs used during induction and maintenance of anesthesia are also known to cause plasma glucose derangement along with surgical stress response, which can lead to adverse postoperative morbidity. Aim: To study the effect of blood glucose level at specified time intervals with intravenous Propofol and Etomidate. Materials and Methods: Sixty cases requiring general anesthesia, belonging to class 1 and 2 of American Society of Anesthesiology were selected. Patients were preoxygenated and premedication drugs were given and induced with either Propofol 2 mg/kg or Etomidate 0.3 mg/kg. Blood glucose was measured before premedication, at 5th minute and at 15th minute respectively. Statistical analysis done using Student t-test for parameters on continuous scale and Chi-square test for parameters on categorical scale. p - value of less than 0.05 was considered statistically significant. Results: The blood glucose in Etomidate Group increased compared to premedication value (84.7 ± 15.37 to 92.5 ± 17.09) and was statistically significant (p - value 0.0167). In Propofol Group, variation in blood glucose level was not significant (88.26 ± 15.47 to 87.0.5 ± 12.84). There was no significant increase in Heart rate, SBP, DBP & MAP at T5 & T15 in both the groups. Conclusion: In the current study, increase in blood glucose in nondiabetic patients following induction was found to be significantly high with Etomidate when compared with Propofol.